Webb20 juli 2014 · In the Trastuzumab for GAstric cancer (ToGA) study, trastuzumab plus chemotherapy improved median overall survival by 2.7 months in patients with human … WebbCancer stem cells (CSCs) are a subpopulation of tumor cells that can drive tumor initiation and can cause relapses. These cells are seen as drivers of tumor establishment and growth, often correlated to aggressive, heterogeneous and therapy-resistant tumors. Novel tumor-specific antigens (TSAs) and tumor-associated antigens (TAAs) specifically …
Pertuzumab, trastuzumab, and chemotherapy in HER2-positive …
Webb14 juli 2024 · Trastuzumab for Gastric Cancer (ToGA) study, an open-label phase III, randomized controlled trial, showed that an addition of trastuzumab to capecitabine or 5-FU and cisplatin demonstrated a clinical benefit compared to chemotherapy alone in terms of tumor response and is now considered to be the standard of care for HER2-positive GC. Webb20 juni 2009 · The phase III Trastuzumab for Gastric Cancer (ToGA) study was the first trial to demonstrate a significant therapeutic benefit of trastuzumab, a humanized monoclonal antibody to HER2, in ... power automate assign record dataverse
HER2 Regimen for Metastasis Gastric Cancer in ToGA trial and …
WebbZhu WG, Xua DF, Pu J et al. A randomized, controlled, multicenter study US Gastric Cancer Consortium. J Clin Oncol 2015; 33: 3874–3879. comparing intensity-modulated ... 60: 1449–1472. advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, 99. D’Ugo D, Biondi A, Tufo A, Persiani R. Follow-up: the evidence ... Webb20 maj 2013 · This analysis assessed treatment outcome according to tumor HER2 status (a pre-defined subgroup) and EGFR expression in EXPAND study pts, finding that pts with HER2 +ve tumors had a longer median overall survival. 4021 Background: In the EXPAND study adding cetuximab to first-line capecitabine and cisplatin chemotherapy (CT) failed … Webb30 nov. 2024 · Gastric adenocarcinoma is by far the most common form of gastric cancer (GC) and is a highly lethal form of cancer arising from the gastric epithelium. GC is an important area of focus of the medical community, given its often late-stage of diagnosis and associated high mortality rate. While surgery and chemotherapy remain the primary … tower of fantasy customization code