Thymidylate synthase翻译
WebbThymidylate synthase (TS) is a major target in the chemotherapy of colorectal cancer and some other neoplasms while raltitrexed (Tomudex, ZD1694) is an antifolate inhibitor of … WebbHuman thymidylate synthase adopts two different conformations, named active and inactive, that equilibrate with each other . The equilibrium position depends on mutations [31,32], on binding of substrates/substrate analogs/inhibitors either in the active site cavity or at the dimer interface, and on crystallization conditions [15,32,33,34].
Thymidylate synthase翻译
Did you know?
WebbPrognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients Hong-Yun Zhao,1,* Guo-Wei Ma,1,* Ben-Yan Zou,1,* Mei Li,1 Su-Xia Lin,1 Li-Ping Zhao,2 Ying Guo,1 Yan Huang,1 Ying Tian,1 Dan Xie,1 Li Zhang1 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative … WebbConsequently, new targets for antibiotics are in high demand. Flavin-dependent thymidylate synthase (FDTS), which is not present in humans and is responsible for the biosynthesis of a DNA building block in several human pathogens (e.g., M. tuberculosis, B. anthracis, H. pylori), is one such novel target.
Webb21 juni 2016 · Thymidylate synthase is an attractive target for antibiotic and anticancer drugs due to its essential role in the de novo biosynthesis of the DNA nucleotide thymine. The enzymatic reaction is initiated by a nucleophilic activation of the substrate via formation of a covalent bond to an active site cysteine. WebbWith the aim to identify novel inhibitors of parasitic nematode thymidylate synthase (TS), we screened in silico an in-house library of natural compounds, taking advantage of a model of nematode TS three-dimensional (3D) structure and choosing candidate compounds potentially capable of enzyme binding/inhibition. Selected compounds were …
Webb15 apr. 2016 · Thymidylate is synthesised de novo from deoxyuridylate and methylenetetrahydrofolate by thymidylate synthase (TYMS), with the enzymes dihydrofolate reductase (DHFR) and serine hydroxymethyltransferase (SHMT) or methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) which are required to regenerate … Webb31 juli 2001 · Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized to dTTP for DNA synthesis.
Webb词典,最权威的学习词典,为您提供thymidylate synthetase的在线翻译,thymidylate synthetase是什么意思,thymidylate synthetase的真人发音,权威用法和精选例句等。
WebbUniProtKB reviewed (Swiss-Prot) Organism. Enterobacteria phage T4 (Bacteriophage T4) Amino acids. 286. Protein existence. Evidence at protein level. Annotation score. 3/5. coffee high school football gaThymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP … Visa mer The following reaction is catalyzed by thymidylate synthase: 5,10-methylenetetrahydrofolate + dUMP $${\displaystyle \rightleftharpoons }$$ dihydrofolate + dTMP By means of reductive Visa mer The use of TS inhibitors has become a main focus of using TS as a drug target. The most widely used inhibitor is 5-fluorouracil (5-FU), which acts as an antimetabolite that irreversibly inhibits TS by competitive binding. However, due to a low level of 5-FU … Visa mer In the proposed mechanism, TS forms a covalent bond to the substrate dUMP through a 1,4-addition involving a cysteine nucleophile. The substrate tetrahydrofolate donates a methyl group to the alpha carbon while reducing the new methyl on dUMP to … Visa mer • Carreras CW, Santi DV (1995). "The Catalytic Mechanism and Structure of Thymidylate Synthase". Annual Review of Biochemistry. 64 (1): 721–762. doi: • Banerjee D, Mayer … Visa mer Thymidylate synthase (TS) plays a crucial role in the early stages of DNA biosynthesis. DNA damage or deletion occur on a daily basis as a result of both endogenous and environmental factors. Such environmental factors include ultraviolet damage … Visa mer Click on genes, proteins and metabolites below to link to respective articles. Visa mer • Pyrimidine analogues • Thymidylate synthase inhibitor • Thymidine kinase Visa mer coffee high trojan football liveWebbPrognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients Hong-Yun Zhao,1,* Guo-Wei Ma,1,* Ben-Yan Zou,1,* Mei Li,1 Su-Xia Lin,1 … coffee hip-hop \u0026 mental healthWebbThymidylate synthase is a folate-dependent enzyme that catalyzes the reductive methylation of 2′-deoxyuridine-5′-monophosphate (dUMP) by the reduced folate 5,10 … coffee highlands ranch coWebb在社会认知理论的基础上,通过多元回归分析对媒体宣传与绿色消费行为的关系机制进行研究,并探究了自我效能和个人结果期望在媒体宣传与绿色消费行为之间的中介作用.实证检验结果发现:传统媒体对消费者绿色消费行为的影响不显著,新媒体正面影响了消费者的绿色消费行为.同时,自我效能和个人 ... coffee high school florence alabamaWebb中国资本市场改革开放30年来，各种资金融通渠道都得到了突飞猛进的发展，但不可否认债务融资仍占据了上市公司资金来源的半壁江山，因此债务的融资成本在很大程度上能够通过限制公司的资本存量而阻碍其投资、扩张速度。那么，对债务成本影响因素的研究就可以指导资金需求方正确地降低 ... cambridge university senate houseWebbThymidylate Synthase Tymidylatsyntas Engelsk definition. An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to … coffee high school florence al alumni