Mitophagy dysfunction
Web5 okt. 2024 · Appropriate mitophagy can be considered as a protective process against apoptosis, but excessive mitophagy can also lead to non-apoptotic cell death, and mitochondrial dysfunction caused by defects of mitophagy can also promote tumour growth. 124, 125 It has been reported that mitophagy can improve cancer cell survival … Web13 apr. 2024 · Genetic factors and hypothalamic or pituitary dysfunction can cause gonadal dysfunction by disrupting the HPG axis. ILLUSTRATION: A. MASTIN/SCIENCE. Defects at one or more levels of the hypothalamic–pituitary–gonadal ... post-translational regulation, and mitophagy (19, 20), expanding the genetic understanding of POI.
Mitophagy dysfunction
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Web1 apr. 2024 · Mitochondrial Dysfunction Lies at the Heart of Parkinson’s Disease. PD (see Glossary) is a common neurodegenerative disorder characterised by loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). This results in the loss of dopaminergic inputs in the striatum and the characteristic motor symptoms associated … Web2 jun. 2024 · The mitochondrion is rightly known as the cell’s “powerhouse”, converting nutrients from the food we eat into energy that can be used by the cell (in the form of a molecule called ATP). Mitochondria are unusual organelles in that they possesses their own DNA, known as mitochondrial DNA (mtDNA). mtDNA is found within each mitochondrion ...
WebMitochondrial dysfunction is a common pathological feature and contributes to the neurodegeneration in both transgenic animal models and human AD patients [ 4, 5, 6 ]. Mitophagy is a selective form of autophagy responsible for the removal of … WebMitochondrial dysfunction is a common pathological feature and contributes to the neurodegeneration in both transgenic animal models and human AD patients [ 4, 5, 6 ]. …
Web11 apr. 2024 · Neurodegenerative disorders are characterized by the progressive loss of neuronal structure or function, resulting in memory loss and movement disorders. Although the detailed pathogenic mechanism has not been elucidated, it is thought to be related to the loss of mitochondrial function in the process of aging. Animal models that mimic the … WebIn vivo, the application of mitochondria-targeted antioxidants could significantly improve renal function and mitochondrial dysfunction, reduce NLRP3 inflammasome activation, and alleviate renal injury. 115 In hyperuricemia-induced CKD, PINK1/parkin-mediated mitophagy was impaired, thereby activating NLRP3, resulting in increased production of …
Web30 okt. 2024 · Treatment with various inducers of mitophagy (rapamycin, deferiprone, and MitoTEMPO) significantly increased mitophagy and decreased mtDNA DAMPs levels in …
Web11 apr. 2024 · Additionally, stimulation of mitophagy by adenovirus-mediated Parkin or Autophagy-related protein 7 (Atg7) overexpression aggravated PBDE-47-induced … ridge\u0027s a8Web10 uur geleden · L‐carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1‐Parkin ‐dependent mitophagy through the CPT1a‐PHB2‐PARL pathways ridge\u0027s a9WebAdditionally, stimulation of mitophagy by adenovirus-mediated Parkin or Autophagy-related protein 7 (Atg7) overexpression aggravated PBDE-47-induced mitophagosome accumulation, mitochondrial dysfunction, neuronal apoptosis and death. Conversely, suppression of mitophagy by the siRNA knockdown of Atg7 rescued PBDE-47-induced … ridge\u0027s abWebOur study provides the first indication that mitophagy acts as a key player modulating bioenergetic capacity in neurons and that mitophagy dysfunction is involved in AD-linked metabolic deficiency. PRKN-mediated mitophagy is initiated with PRKN translocation onto damaged mitochondria followed by their sequestration within autophagosomes [ Citation … ridge\u0027s a1Web1 aug. 2024 · Mitophagy could also be regulated by BNIP3 and NIX under hypoxic conditions. BNIP3 and Nix are receptors that contain identical N-terminal LIRs (LC3-interacting regions). The phosphorylation of Ser17 and Ser24 of BNIP3 and phosphorylation of Ser34 and Ser35 of NIX promote the interaction between LIR and LC3, thereby … ridge\u0027s 9xWebAbstract. The process of mitophagy, in which mitochondria are selectively turned over at the autophagolysosome, plays a central role in both eliminating dysfunctional mitochondria … ridge\u0027s a6WebMitophagy serves as a predominant part of the mitochondrial quality control system, which also plays a vital role in the inflammatory response caused by mitochondrial … ridge\u0027s 9y