Cisplatin sensitivity

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August undefined, 2024

Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … WebMay 1, 2003 · In such an instance, cancer cells may escape the apoptotic consequence of cisplatin exposure but still sustain major genotoxic insults. Considering that apoptosis …

Bonn researchers elucidate a mechanism underlying cisplatin …

WebOct 13, 2024 · Extensive research has been conducted to understand and overcome platinum resistance, and mechanisms of resistance can be categorized into several broad biological processes, including (1)... WebDetermining the factors that influence cellular sensitivity to cisplatin is thus important for understanding the anticancer activity of cisplatin and for developing a more effective platinum-based chemotherapy. The cytotoxicity of cisplatin arises from its ability to react with DNA and form covalent DNA adducts ( 4 ). dallas college upward bound

CircZNF609 promotes bladder cancer progression and inhibits cisplatin …

WebFactors contributing to the observed cisplatin sensitivity include defective DNA damage repair and a hypersensitive apoptotic response to DNA damage. Nonetheless, around 10 … WebDec 2, 2024 · However, the underlying role and mechanism of circZNF609 in bladder cancer (BCa) development and cisplatin chemosensitivity were unknown. Quantitative real-time PCR (qRT-PCR) was applied to determine the expression of circZNF609, microRNA 1200 (miR-1200) and CDC25B in BCa cells and tissues. WebMar 15, 2024 · The results indicated that URI knockdown increased the sensitivity of cells to cisplatin by inhibiting proliferation and promoting apoptosis. The levels of P-ATM, P-CHK2 and γH2AX were detected by Western blot. Increased levels of P-ATM, P-CHK2, and γH2AX were observed in cisplatin treated cells, indicating that cisplatin induced a DNA … dallas colts tickets

Uptake of the anticancer drug cisplatin mediated by the copper ... - PNAS

Cisplatin sensitivity mediated by NKX2-1 in lung adenocarcinoma …

WebFor the first time, our study implies that d-borneol enhanced cisplatin sensitivity by inducing ferroptosis, promoting autophagy and inhibiting EMT progression, thereby … WebSep 24, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms. Its most acceptable mechanism involves the formation of DNA–platinum adducts by interacting with purine bases, activating several signal transduction pathways, and silencing or activating several genes which finally leads to apoptosis. dallas colleges universities for two coursesWebSep 30, 2013 · In cisplatin-sensitive TC cell lines and the EC component of chemo-sensitive tumours, low levels of cytoplasmic p21 similarly correlated with high expression of Oct4 and of miRs belonging to the miR-17/106b seed family (Ref. Reference Koster40). P53 activity can be influenced by MDM2. biracial twins twenty years later

"WebMar 8, 2024 · XPV fibroblasts are sensitive to UV light and cisplatin but are corrected by transfection of POLHcDNA [1,13]. In this context, it is reasonable to postulate that human germline POLHvariants can alter the TLS activity and thus modify the susceptibility to toxic effects of UV and cisplatin in genetically affected individuals. " - Cisplatin sensitivity

Cisplatin sensitivity

Differential expression of collateral sensitivity or resistance to ...

WebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with … WebMar 15, 2003 · Cisplatin-resistance cell lines CP70, C30, and C200 were produced by intermittent, incremental exposure of the sensitive parental A2780 cell line to various concentrations of cisplatin. OVCAR-4 and OVCAR-10 cell lines were developed from patients who were clinically refractory to platinum-based chemotherapy (16, 17).

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WebSensitivity to cisplatin in the different groups was measured as the IC 50 concentration after transfection. Growth inhibition rate of the A549 cells was 52.0% under the effect of cisplatin at an IC 50 concentration of 0.8 μg/mL but decreased to 37.6% after transfection with miR-195-5p-ASO. WebMay 17, 2012 · Cisplatin sensitivity correlated with the expression of 454 unique genes (P<0.01), corresponding to 68 pathways. Twenty-three of …

WebNov 12, 2024 · Commonly reported side effects of cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of … WebJan 4, 2024 · Although many mechanisms of cisplatin resistance have been proposed, the key mechanisms of such resistance remain elusive. The RNA binding protein with multiple splicing (RBPMS) binds to nascent RNA transcripts and regulates splicing, transport, localization, and stability.

WebJul 14, 2024 · Mechanismly, propofol enhances cisplatin sensitivity of NSCLC through miR-486-5p/RAP1-NF-κB axis. The finding provides a deeper understanding about the … WebMay 1, 2003 · In such an instance, cancer cells may escape the apoptotic consequence of cisplatin exposure but still sustain major genotoxic insults. Considering that apoptosis may be impaired, using...

WebOct 7, 2002 · Work from many laboratories has implicated DNA as a critical target for cisplatin cytotoxicity, the most revealing evidence being the hypersensitivity to cisplatin of both prokaryotic and eukaryotic cells deficient in DNA repair ( 3–5 ).

WebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, novel … dallas colts highlightsWebJul 26, 2024 · Background: Cisplatin (CDDP) is commonly used to treat non-small cell lung cancer (NSCLC), but the appearance of drug resistance greatly hinders its … dallas comic and toy showWebNov 15, 1987 · Two sublines were derived from a human bladder carcinoma continuous cell line (RT112-P), one by exposure to fractionated X-irradiation (RT112-DXR8) and the other by continuous exposure to cisplatin (RT112-CP). RT112-DXR8 cells were 1.6- to 2-fold more sensitive to cisplatin and 2 analogues, carbopla … birac infoWebDec 9, 2024 · By analysing RNA-seq data in OSCC cells treated with vitamin D and cisplatin, we found that lipocalin 2 (LCN2) was an important modulator of cisplatin … dallas comedy club parkingWebCarboplatin sIgE is very specific but less sensitive. In contrast, oxaliplatin sIgE had higher sensitivity but lower specificity. Analysis of our data suggests that oxaliplatin exposure … dallas colts footballWebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. ... USP14 levels were higher in DDP-resistant lung cancer compared to DDP-sensitive lung ... bir acknowledgement certificateWebA recent study indicated that NKX2-1 may modulate cellular sensitivity to cisplatin by modulating the β-catenin pathway through phosphorylation of AKT . We here … dallas comedy club speed dating