Cisplatin renal clearance
WebSep 16, 2024 · The mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m 2 following administration of 100 mg/m 2 as 2-hour or 6- to 7-hour infusions, respectively. The renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing ... WebThe clearance (or total clearance) of a drug is the sum of the clearances of the eliminating organs, mainly the kidneys and the liver: CL = CL renal+CL hepatic. The hepatic clearance tends to be lower in elderly than in younger patients but that is …
Cisplatin renal clearance
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WebFeb 16, 2024 · This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and … WebJun 8, 2024 · The renal clearance of free platinum is nonlinear and variable and is dependent on dose, urine flow rate, and individual variability in the extent of active …
WebCisplatin renal clearance, total clearance, and the percentage of the dose excreted unchanged in urine were significantly lower with the longer infusion. Total clearance was 345 +/- 97.0 mL/min/m2 after the two-hour infusion and 268 +/- 70.7 mL/min/m2 after the 24-hour infusion (P less than .0001). WebNational Center for Biotechnology Information
WebApr 19, 2024 · The mean renal clearance of cisplatin exceeds creatinine clearance and was 62 mL/min per m² and 50 mL/min per m² following administration of 100 mg/m² as 2-hour or 6-to 7-hour infusions, respectively. Plasma concentrations of the parent compound, cisplatin, decrease monoexponentially with a half-life of about 20 to 30 minutes … WebCisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost all patients treated...
WebThe mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m 2 following administration of 100 mg/m 2 as 2 hour or 6 hour to 7 hour infusions, respectively. The renal clearance of free …
WebPretreatment with cisplatin has been reported to increase MTX toxicity, possibly by decreasing renal clearance (40). AKI prolongs extrarenal toxicity (myelosuppression … howard university job postingWebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has been focused on cisplatin-induced acute kidney disease, whereas the mechanism of chronic kidney disease after cisplatin chemotherapy is largely unknown. In the present study, … howard university jobs hospitalWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … how many laws are broken dailyWebApr 12, 2024 · OCT2 exerts its action through cisplatin transport into renal tubular epithelial cells . Consequently, OCT2 is responsible for the cellular uptake of cisplatin and, thus, for its intracellular accumulation. ... Indeed, from 5% to 15% of the patients with both estimated creatinine clearance (eCrCl), expressed in milliliters/minute, ... howard university irb addressWebThe renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing molecules are … howard university in which countryWebCisplatin dose adjustment in patients with renal impairment must be improved. Estimating GFR with the aMDRD formula and adding an intermediary level of dose reduction for … how many laws are created each yearWebIn the kidney, cisplatin is absorbed by renal cells via passive diffusion. During excretion, cisplatin and its metabolites are secreted and reabsorbed in the renal tubules during … howard university it department