Cisplatin hepatotoxicity

WebCisplatin (cis-diamminedichloroplatinium, CDDP), one of the most widely used chemotherapeutic drugs for a variety of tumors, exhibits anticancer activity via formation of CDDP-DNA adducts. 6 However, its clinical use has been hampered by the intrinsic and adaptive resistances of the tumor cells along with severe toxic effects, which greatly … Webabstract = "Generation of free radicals in the kidney cortex plays an important role in the pathogenesis of cisplatin-induced dysfunction of renal proximal tubule cells.

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WebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … WebThe results suggest that the plant extract (250 and 500 mg/kg) was effective in significantly altering the indices of cisplatin induced dysfunction of renal proximal tubule cells under oxidative stress by decreasing the concentration of … tsc ledger https://steffen-hoffmann.net

Gut microbiota accelerates cisplatin-induced acute liver …

WebMultivariate analysis showed that HIPEC regimen was the main risk factor of hepatotoxicity induced by HIPEC, with cisplatin + docetaxel being an independent risk factor of the HIPEC-induced hepatotoxicity. Open HIPEC techniques and HIPEC duration more than 60 minutes tend to increase the incidence of hepatotoxicity. WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. WebCisplatin is one of the most potent cytotoxic anticancer medicines; nonetheless, hepatotoxicity and lymphotoxicity are two of its significant adverse effects, which … philly\\u0027s hottest yoga

Gut microbiota accelerates cisplatin-induced acute liver …

Category:Boobalan Raja et al. / Journal of Pharmacy Research 2010, …

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Cisplatin hepatotoxicity

Molecular mechanisms of cisplatin-induced nephrotoxicity: a …

WebTo date, no published guidelines exist for managing a cisplatin overdose. The major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, … WebDec 20, 2024 · Altered hepatic drug metabolism due to underlying liver disease can result in higher or more persistent drug levels, thereby causing increased systemic toxicity (particularly myelosuppression) or worsening of liver function because of …

Cisplatin hepatotoxicity

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WebDrug-induced liver injury (DILI) is the most common cause of acute liver failure worldwide. 1, 2 Cisplatin (CP) is one of the most common and potent anti-neoplastic agents used against testicular, ovarian, cervical, as well as bladder malignancies. 3 – 6 Despite its effectiveness, CP use is limited due to its serious toxic side effects such as … WebApr 13, 2024 · Cisplatin hepatotoxicity was associated with gut microbiota dysbiosis. Multi-omics results revealed that dysbiosis of the gut microbiota accompanied cisplatin …

WebApr 1, 1993 · To report a case of possible cisplatin-associated hepatotoxicity. CASE SUMMARY: A 69-year-old man received three cycles of cisplatin (100 mg/m 2 ) and … WebJan 14, 2024 · This study was designed to investigate the protective effects of Centella asiatica (CA) on cisplatin-induced hepatotoxicity and to clarify the underlying …

WebCisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin mediates its tumorcidal effects via a number of different cytotoxic mechanisms. Although it is best known for DNA damage, … WebApr 13, 2024 · Conclusions: This study elucidated the mechanism by which gut microbiota mediates cisplatin hepatotoxicity through enhanced inflammatory response and …

WebHepatotoxicity was induced in animals by an intraperitoneal injec-tion of acetaminophen (750 mg/kg body weight) in a freshly prepared physi-ological saline solution kept in warm boiling water bath and used after cooling at 370C, as a single dose on the first day. The rats were randomly divided into five groups of six animals each as given below.

WebAn association between cisplatin administration and hepatotoxicity is proposed in this patient. Conclusions: This patient may have experienced cisplatin-induced liver … philly\\u0027s grill ontario caWebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … ts cliWebFeb 2, 2024 · There is substantial evidence that protective medications can alleviate drug-induced organ toxicity by modulating both Nrf2 and NF-κB signaling pathways. Thus, it has become increasingly important to explore the crosstalk mechanism between Nrf2 and NF-κB in drug-induced toxicity. philly\\u0027s hospitality laneWebSynergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity. … tsc lesson observationphilly\u0027s hospitality laneWebOne of greatest key mechanisms of Cis toxicity is the induction of oxidative stress. Under normal conditions, ROS are controlled by cells through harmonizing the production of ROS with their removal by scavenging system. Oxidative stress results in extreme damage of cellular proteins, lipids and DNA, leading to critical cellular injuries. philly\u0027s grillWebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). tsc liam