WebNational Center for Biotechnology Information Webb7是一類在活化的抗原呈遞細胞（apc）表面的外周膜蛋白，能與t細胞表面的cd28或cd152（ctla-4）等蛋白識別，從而與mhc-tcr識別形成「共刺激」信號或「共抑制」信號 …

什么是B7分子 - 百度知道

WebFeb 21, 2024 · B7-H3主要以膜蛋白和可溶形式存在，可溶的B7-H3（soluble B7-H3, sB7-H3）由膜蛋白经金属蛋白酶剪切而来[4]。此外，在外泌体和其他胞外小泡中也发现了B7-H3蛋白。 B7-H3是一种T细胞共抑制分子，具有部分共刺激功能。B7-H3可有效抑制T细胞和NK细胞功能，对骨发育也有 ... B7 is a type of integral membrane protein found on activated antigen-presenting cells (APC) that, when paired with either a CD28 or CD152 (CTLA-4) surface protein on a T cell, can produce a costimulatory signal or a coinhibitory signal to enhance or decrease the activity of a MHC-TCR signal between the APC and the T cell, respectively. Binding of the B7 of APC to CTLA-4 of T-cells causes inhibition of the activity of T-cells. closest self car wash

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WebNov 15, 2013 · The B7-H3 (B7-homolog 3 or CD276) is a type I transmembrane protein and a member of the B7 family. B7-H3 is expressed in many tissues and in antigen-presenting cells. Its functions and counter receptor (s) remain unclear. The expression of the B7-H3 protein by the tumor microenvironment and tumor cells modifies the antitumor immune … http://www.medxtmc.com/articles/jlxlb7.html WebApr 24, 2024 · b7h3免疫疗法开发策略鉴于b7-h3对免疫系统的抑制作用和b7-h3在肿瘤细胞的高表达，目前b7-h3靶向免疫疗法的开发策略主要由以下几方面： b7-h3的免疫治疗策略. 1.使用单克隆抗体阻断b7-h3和受体的结合。阻断抗体可以完全阻断b7-h3和受体的结合，解除免疫抑制的作用。 closest see\u0027s candy